From Australian Oceans Data Network
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Peptides that inhibit neuronal nitric oxide synthase

Created 23/06/2025

Updated 23/06/2025

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Neuronal nitric oxide synthase (nNOS) inhibition tests were carried out on peptides in addition to other bioactivity experiments, in particular, antibiotic activity. Inhibition of nNOS was measured by monitoring the conversion of [3H]arginine to [3H]citrulline.Information recorded: individual identifier for sample, peptide sequence, molecular weight, stock concentration (mg/ml), source (native peptide, synthetic derivative), solvent and concentration. To test whether the peptides inhibit nNOS. Peptides tested: aurein, caerin, citropin, cupiennin, dahlein, frenatin, lesueurin, rothein, signiferin, uperin.Sources of native peptides: Cirinia signifera; Cupiennius salei; Litoria aurea, L. caerulea, L. citropa, L. chloris, L. dahlii, L. electrica, L. gilleni, L. gracilenta, L. infrafrenata, L. lesueuri, L. rothii, L. rubella, L. splendida, hybrid L. caerulea/splendida; Uperoleia mjobergii.The first report of neuronal nitric oxide synthase inhibition by a component of a spider venom (Cupiennius salei).Subsets of the data have been used in a number of studies.

Files and APIs

Additional Info

Field Value
Title Peptides that inhibit neuronal nitric oxide synthase
Language eng
Licence Not Specified
Landing Page https://data.gov.au/data/dataset/a479371a-ae0f-4284-b252-5d632d0d4ba2
Contact Point
Australian Ocean Data Network
adc@aims.gov.au
Reference Period 20/11/2017
Geospatial Coverage Australia
Data Portal Australian Oceans Data Network

Data Source

This dataset was originally found on Australian Oceans Data Network "Peptides that inhibit neuronal nitric oxide synthase". Please visit the source to access the original metadata of the dataset:
https://catalogue.aodn.org.au/geonetwork/srv/eng/csw/dataset/peptides-that-inhibit-neuronal-nitric-oxide-synthase1