a479371a-ae0f-4284-b252-5d632d0d4ba2 urn:uuid eng UTF-8 nonGeographicDataset nonGeographicDataset 2025-06-23T11:00:26 creation ISO 19115 2016 Peptides that inhibit neuronal nitric oxide synthase a479371a-ae0f-4284-b252-5d632d0d4ba2 Neuronal nitric oxide synthase (nNOS) inhibition tests were carried out on peptides in addition to other bioactivity experiments, in particular, antibiotic activity. Inhibition of nNOS was measured by monitoring the conversion of [3H]arginine to [3H]citrulline.Information recorded: individual identifier for sample, peptide sequence, molecular weight, stock concentration (mg/ml), source (native peptide, synthetic derivative), solvent and concentration. To test whether the peptides inhibit nNOS. Peptides tested: aurein, caerin, citropin, cupiennin, dahlein, frenatin, lesueurin, rothein, signiferin, uperin.Sources of native peptides: Cirinia signifera; Cupiennius salei; Litoria aurea, L. caerulea, L. citropa, L. chloris, L. dahlii, L. electrica, L. gilleni, L. gracilenta, L. infrafrenata, L. lesueuri, L. rothii, L. rubella, L. splendida, hybrid L. caerulea/splendida; Uperoleia mjobergii.The first report of neuronal nitric oxide synthase inhibition by a component of a spider venom (Cupiennius salei).Subsets of the data have been used in a number of studies. Cupiennin 1a, an antimicrobial peptide from the venom of the neotropical wandering spider Cupiennius salei, also inhibits the formation of nitric oxide by neuronal nitric oxide synthase: Pukala TL, Doyle JR, Llewellyn LE, Kuhn-Nentwig L, Apponyi MA, Separovic F and Bowie JH (2007) Cupiennin 1a, an antimicrobial peptide from the venom of the neotropical wandering spider Cupiennius salei, also inhibits the formation of nitric oxide by neuronal nitric oxide synthase. FEBS Journal 274(7):1778-1784. documentDigital Cupiennin 1a, an antimicrobial peptide from the venom of the neotropical wandering spider Cupiennius salei, also inhibits the formation of nitric oxide by neuronal nitric oxide synthase: Pukala TL, Doyle JR, Llewellyn LE, Kuhn-Nentwig L, Apponyi MA, Separovic F and Bowie JH (2007) Cupiennin 1a, an antimicrobial peptide from the venom of the neotropical wandering spider Cupiennius salei, also inhibits the formation of nitric oxide by neuronal nitric oxide synthase. FEBS Journal 274(7):1778-1784. Host-defence peptide profiles of the skin secretions of interspecific hybrid tree frogs and their parents, female Litoria splendida and male Litoria caerulea: Pukala TL, Bowie JH, Bertozzi T, Donnellan SC, Doyle JR, Surinya-Johnson KH, Liu Y, Jackway RJ, Llewellyn LE and Tyler MJ (2006) Host-defence peptide profiles of the skin secretions of interspecific hybrid tree frogs and their parents, female Litoria splendida and male Litoria caerulea. FEBS Journal 273:3511-3519. documentDigital Host-defence peptide profiles of the skin secretions of interspecific hybrid tree frogs and their parents, female Litoria splendida and male Litoria caerulea: Pukala TL, Bowie JH, Bertozzi T, Donnellan SC, Doyle JR, Surinya-Johnson KH, Liu Y, Jackway RJ, Llewellyn LE and Tyler MJ (2006) Host-defence peptide profiles of the skin secretions of interspecific hybrid tree frogs and their parents, female Litoria splendida and male Litoria caerulea. FEBS Journal 273:3511-3519. nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1: Doyle JR, Brinkworth CS, Wegener KL, Carver JA, Llewellyn LE, Oliver IN, Bowie JH, Wabnitz PA and Tyler MJ (2003) nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1. European Journal of Biochemistry 270: 1141-1153. documentDigital nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1: Doyle JR, Brinkworth CS, Wegener KL, Carver JA, Llewellyn LE, Oliver IN, Bowie JH, Wabnitz PA and Tyler MJ (2003) nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1. European Journal of Biochemistry 270: 1141-1153. The solution structure of frenatin 3, an nNOS inhibitor from the giant tree frog Litoria infrafrenata: Brinkworth CS, Carver JA, Wegener KL, Doyle JR, Llewellyn LE and Bowie JH (2003) The solution structure of frenatin 3, an nNOS inhibitor from the giant tree frog Litoria infrafrenata. Biopolymers 70: 424-434. documentDigital The solution structure of frenatin 3, an nNOS inhibitor from the giant tree frog Litoria infrafrenata: Brinkworth CS, Carver JA, Wegener KL, Doyle JR, Llewellyn LE and Bowie JH (2003) The solution structure of frenatin 3, an nNOS inhibitor from the giant tree frog Litoria infrafrenata. Biopolymers 70: 424-434. New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry: Maclean MJ, Brinkworth CS, Bilusich D, Bowie JH, Llewellyn LE, Doyle JR and Tyler MJ (2006) New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry. Toxicon 47:664-675. documentDigital New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry: Maclean MJ, Brinkworth CS, Bilusich D, Bowie JH, Llewellyn LE, Doyle JR and Tyler MJ (2006) New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry. Toxicon 47:664-675. Amphibian peptides that inhibit neuronal nitric oxide synthase. The isolation of lesueurin from the skin secretion of the Australian Stony Creek frog Litoria lesueuri: Doyle JR, Llewellyn LE, Brinkworth C, Bowie JH, Wegener KL, Rozek T, Wabnitz PA, Wallace JC and Tyler MJ (2002) Amphibian peptides that inhibit neuronal nitric oxide synthase. The isolation of lesueurin from the skin secretion of the Australian Stony Creek frog Litoria lesueuri. European Journal of Biochemistry 269: 100-109. documentDigital Amphibian peptides that inhibit neuronal nitric oxide synthase. The isolation of lesueurin from the skin secretion of the Australian Stony Creek frog Litoria lesueuri: Doyle JR, Llewellyn LE, Brinkworth C, Bowie JH, Wegener KL, Rozek T, Wabnitz PA, Wallace JC and Tyler MJ (2002) Amphibian peptides that inhibit neuronal nitric oxide synthase. The isolation of lesueurin from the skin secretion of the Australian Stony Creek frog Litoria lesueuri. European Journal of Biochemistry 269: 100-109. 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