{"help": "https://data.gov.au/data/api/3/action/help_show?name=package_show", "success": true, "result": {"archived": false, "author_email": null, "contact_point": "unknown", "creator_user_id": "c2fbbe4a-4ba0-4945-808b-67454605a4cf", "duplicate_score": 2, "geospatial_topic": [], "id": "c540e420-ab69-4fee-b76e-551e627ba0a2", "isopen": false, "license_id": "cc-by", "license_title": "Creative Commons Attribution 3.0 Australia", "license_url": "http://creativecommons.org/licenses/by/3.0/au/", "maintainer": null, "maintainer_email": null, "metadata_created": "2025-06-24T14:49:48.237794", "metadata_modified": "2025-10-19T16:16:08.924321", "name": "nsw-improving-anti-chlamydial-responses-in-nsw-koalas", "notes": "Improving anti-chlamydial responses in NSW koalas with a Chlamydia-koala retrovirus combination vaccine.\nKoalas are an endangered species under threat of extinction from several factors, including infections agents. Chlamydia pecorum infection results in morbidity and mortality from ocular and urogenital dis eases while Koala Retrovirus (KoRV) infection has been linked to increased rates of cancer and chlamy diosis. Both C. pecorum and KoRV are endemic in many wild Australian koala populations, with limited treatment options available. Fortunately, vaccines for these pathogens are under development and have generated effective immune responses in multiple trials. \nThe current study aimed to improve vaccine for mulations by testing a novel peptide version of the Chlamydia vaccine and a combination Chlamydia \u2013 KoRV vaccine. Utilising a monitored wild population in Southeast Queensland, this trial followed koalas given either a \u2018Chlamydia only\u2019 vaccine (utilising four peptides from the chlamydial Major Outer Membrane Protein, MOMP), a combination \u2018Chlamydia and KoRV\u2019 vaccine (comprised of the chlamydial peptides plus a KoRV recombinant envelope protein (rEnv)) or no treatment. Clinical observations, C. pecorum and KoRV gene expression, serum IgG, and mucosal immune gene expression were assessed over a 17-month period. Overall, both vaccine formulations resulted in a decrease in chlamydiosis mortality, with decreases in C. pecorum, CD4, CD8b and IL-17A gene expression observed. In addition, the combina tion vaccine group also showed an increase in anti-KoRV IgG production that corresponded to a decrease in detected KoRV-B expression. While these results are favourable, the chlamydial peptide vaccine did not appear to outperform the established recombinant chlamydial vaccine and suggests that a combina tion vaccine formulated with recombinant MOMP plus KoRV rEnv could capitalize on the demonstrated benefits of both for the betterment of koalas into the future.", "num_resources": 3, "num_tags": 1, "organization": {"id": "aeebe9c7-dd8e-43f5-b92d-6b31bf8c9375", "name": "the-university-of-the-sunshine-coast-datansw", "title": "The University of the Sunshine Coast", "type": "organization", "description": "The University of the Sunshine Coast (UniSC) is a regional University located in SE Queensland.  It is a young, ambitious university driven by the belief that community and culture is just as important as a world-class education.  UniSC has grown exponentially since 1996 into a comprehensive university that is a global leader in sustainability, with award-winning facilities spanning five campuses along the South East coast of Queensland.  UniSC is the world\u2019s only university operating within three UNESCO Biosphere Reserves and a UNESCO World Heritage Site, which grants us a unique opportunity to capitalise on the wealth of significant environmental treasures around us, and continuously work to champion sustainability.  In the 2023 Times Higher Education (THE) Impact Rankings, UniSC is the top ranked Queensland university, and in the top two per cent globally, for \u2018Overall Impact.\u2019 See more at https://www.usc.edu.au", "image_url": "", "created": "2025-06-25T00:49:52.353206", "is_organization": true, "approval_status": "approved", "state": "active"}, "original_harvest_source": {"site_url": "https://data.nsw.gov.au/data/", "href": "https://data.nsw.gov.au/data/dataset/nsw-improving-anti-chlamydial-responses-in-nsw-koalas", "title": "DataNSW"}, "original_name": "nsw-improving-anti-chlamydial-responses-in-nsw-koalas", "owner_org": "aeebe9c7-dd8e-43f5-b92d-6b31bf8c9375", "private": false, "promotion_level": "0", "remote_last_updated": "2025-10-08 07:37:07.979561", "spatial": "New South Wales", "state": "active", "temporal_coverage_from": "2019-05-12 00:00:00", "temporal_coverage_to": "2021-05-31 00:00:00", "title": "Improving anti-chlamydial responses in NSW koalas with a Chlamydia-koala retrovirus combination vaccine", "type": "dataset", "unpublished": false, "url": null, "version": null, "extras": [{"key": "harvest_object_id", "value": "6845b6a0-dc92-4a23-9f63-8777062df51b"}, {"key": "harvest_source_id", "value": "9ebac586-8e51-4904-9f6c-d9b79726659a"}, {"key": "harvest_source_title", "value": "DataNSW"}], "resources": [{"cache_last_updated": null, "cache_url": null, "created": "2025-10-08T07:37:08.011973", "datastore_active": false, "datastore_contains_all_records_of_source_file": false, "format": "PDF", "hash": "", "id": "fd12a283-7dd3-4a98-802e-83ba8a2a3a38", "last_modified": null, "metadata_modified": "2025-10-19T16:15:02.143628", "mimetype": "application/pdf", "mimetype_inner": null, "name": "Reduction of Chlamydia pecorum and Koala Retrovirus subtype B expression in wild koalas vaccinated with novel peptide and peptide/ recombinant protein formulations", "package_id": "c540e420-ab69-4fee-b76e-551e627ba0a2", "position": 0, "resource_type": null, "size": null, "state": "active", "url": "https://datasets.seed.nsw.gov.au/dataset/e8e31e40-e890-4e47-9023-8842df2b0498/resource/7bf91094-3e95-4d4a-a264-b3d0c69805a5/download/2019_09_scientificpaper.pdf", "url_type": null, "zip_extract": false}, {"cache_last_updated": null, "cache_url": null, "created": "2025-10-08T07:37:08.011979", "datastore_active": false, "datastore_contains_all_records_of_source_file": false, "format": "XLS", "hash": "", "id": "77ed7411-4959-4d61-ac1d-d66ea0e446a1", "last_modified": null, "metadata_modified": "2025-10-19T16:15:02.144640", "mimetype": "application/vnd.ms-excel", "mimetype_inner": null, "name": "Data 2019_09", "package_id": "c540e420-ab69-4fee-b76e-551e627ba0a2", "position": 1, "resource_type": null, "size": null, "state": "active", "url": "https://datasets.seed.nsw.gov.au/dataset/e8e31e40-e890-4e47-9023-8842df2b0498/resource/f5604966-36c1-4208-a596-f52e0a9b6295/download/2019_09_data.xls", "url_type": null, "zip_extract": false}, {"cache_last_updated": null, "cache_url": null, "created": "2025-10-08T07:37:08.011981", "datastore_active": false, "datastore_contains_all_records_of_source_file": false, "format": "PDF", "hash": "", "id": "cf0e9b0a-d35c-4776-818e-ea2feb9a70c6", "last_modified": null, "metadata_modified": "2025-10-19T16:15:02.196010", "mimetype": "application/pdf", "mimetype_inner": null, "name": "Data Quality Statement", "package_id": "c540e420-ab69-4fee-b76e-551e627ba0a2", "position": 2, "resource_type": null, "size": null, "state": "active", "url": "https://datasets.seed.nsw.gov.au/dataset/e8e31e40-e890-4e47-9023-8842df2b0498/resource/ae5faacf-f825-499b-816e-c47228a71502/download/dqs-koala-research-plan-proj-2029_09.pdf", "url_type": null, "zip_extract": false}], "tags": [{"display_name": "Environment", "id": "7bc851e2-be5b-4dea-b133-b57a2ab0c7e9", "name": "Environment", "state": "active", "vocabulary_id": null}], "groups": [], "relationships_as_subject": [], "relationships_as_object": []}}